Expression of osteopontin in colorectal cancer and hepatic metastatic cancer tissues and its clinical significance
10.3760/cma.j.issn.1007-631X.2015.05.014
- VernacularTitle:骨桥蛋白在结直肠癌及其肝转移组织的表达及临床意义
- Author:
Yuan LYU
;
Shiyong LI
;
Ping AN
;
Huiyun CAI
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Prognosis;
Osteopontin
- From:
Chinese Journal of General Surgery
2015;30(5):383-385
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of osteopontin in colorectal cancer and hepatic metastatic cancer and its clinical significance.Methods The expression of osteopontin in 76 cases of colorectal cancer tissues,30 para carcinoma normal mucosa,liver metastatic tumor tissues in 16 patients was examined by immunohistochemical SP staining method.Results The expression rates of osteopontin in normal mucosa,colorectal cancer tissues and liver metastatic cancer tissues were 6.7％ (2/30),69.7％ (53/76),75.0％ (12/16) respectively.The expression rates of osteopontinin colorectal cancer and liver metastatic cancer was significantly higher than those in the normal mucosa (respectively x2 =34.273,23.014,all P ＜ 0.001).The expression of osteopontin was related to infiltration depth,lymph node metastasis,and distant metastasis (respectively x2 =14.347,6.577,7.278,5.537,all P ＜ 0.05).There was no significant difference in the sex and age.Kaplan-Meier survival analysis showed that patients with osteopontin positive had poor prognosis compared with osteopontin negative patients (P ＜ 0.001).Conclusions The expression of osteopontin is closely related to the invasion and metastasis of colorectal carcinoma,a hopeful indicator for the prognosis of colorectal cancer.
