High expression of PIK3CB is an independent prognostic predictor for gastric adenocarcinoma
10.3760/cma.j.issn.1007-631X.2014.12.012
- VernacularTitle:磷脂酰肌醇-3激酶催化亚基β在胃癌组织中的表达及其临床意义
- Author:
Wei ZHAI
;
Mei LI
;
Jianqiang DONG
;
Weidong YU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Phosphatidylinositol 3-kinases;
Prognosis
- From:
Chinese Journal of General Surgery
2014;29(12):934-936
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between the expression of phosphoinositide-3 kinase,catalytic subunit beta (PIK3CB) and the clinicopathologic characteristics in gastric adenocarcinoma tissues.Methods Immunohistochemistry was used to determine PIK3CB expression in human gastric adenocarcinoma tissues and matched adjacent tissues.The correlation between PIK3CB expression and the patients' clinicopathological characteristics and prognosis was statistically analyzed.Results PIK3CB is highly expressed in gastric adenocarcinoma tissues (positive rate 63.8％) compared with matched adjacent tissues (positive rate 45.7％) (x2 =9.139,P =0.003).PIK3CB expression is significantly correlated with tumor size (x2 =8.677,P =0.003),infiltration (x2 =9.306,P =0.025),and clinical stage (x2 =8.242,P =0.041) ; Level of PIK3CB expression has a significant impact on prognosis (x2 =25.644,P =0.000).Multivariate analyses showed that high PIK3CB expression is an independent poor prognostic factor for overall survival (HR =15.785,95％ CI:1.943-7.805,P =0.000).Conclusions Upregulated PIK3CB is correlated with poor postoperative prognosis of gastric carcinoma.
