Detection of serum osteopontin in patients with pemphigus vulgaris

VernacularTitle:寻常型天疱疮患者血清骨桥蛋白的检测
Author: Guiying SUO ; Ping FU
Publication Type:Journal Article
Keywords: Pemphigus; Osteopontin; Enzyme-linked immunosorbent assay
From: Chinese Journal of Dermatology 2015;48(1):53-54
CountryChina
Language:Chinese
Abstract: Objective To investigate the role of serum osteopontin in the occurrence of pemphigus vulgaris (PV).Methods Enzyme-linked immunosorbent assay was conducted to determine serum levels of osteopontin in 31 patients with PV and 35 healthy human controls.Statistical analysis was carried out by t test and Spearman rank correlation analysis with the SPSS 17.0 software and Excel.Results Serum levels of osteopontin were significandy higher in patients with PV than in healthy controls (P ＜ 0.01),in patients with mucocutaneous involvement than in those with only cutaneous involvement (P ＜ 0.05),and in patients with complicated infections than in those without (P ＜ 0.01).There was a positive correlation between serum levels of osteopontin and anti-Dsg3 antibody in patients with PV (rs =0.489,P ＜ 0.01).Conclusions Serum levels of osteopontin are increased in patients with PV,especially in those with mucocutaneous involvement,and positively correlated with PV-related antibody titers.