Clinicopathologic analysis of 60 cases of pityriasis lichenoides et varioliformis acuta
10.3760/cma.j.issn.0412-4030.2015.02.007
- VernacularTitle:急性痘疮样苔藓样糠疹60例临床病理分析
- Author:
Xiulian XU
;
Guangping WANG
;
Hao CHEN
;
Yiqun JIANG
;
Xuesi ZENG
;
Hong JIA
;
Jianfang SUN
- Publication Type:Journal Article
- Keywords:
Pityriasis lichenoides,varioliformis acuta;
Pathology
- From:
Chinese Journal of Dermatology
2015;48(2):90-93
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinicopathologic features of pityriasis lichenoides et varioliformis acuta (PLEVA).Methods A retrospective analysis was performed.Clinical and histological data were collected from 60 patients with PLEVA.The clinicopathologic features of PLEVA were analyzed.Results Among the 60 patients with PLEVA,32 (53.3％) were aged 2-18 years,and 28 (46.7％) aged 19-49 years.Skin lesions were distributed in a diffuse pattern in 50 (83.3％) patients,in a central pattern in 2 (3.3％) patients,and in a peripheral pattern in 8 (13.4％) patients.Nineteen (31.6％) patients had a history of upper respiratory infection.Histopathological examination revealed liquefactive degeneration of basal cells and perivasculitis in the dermis in all the 60 cases,neutrophil abscess formation in the stratum corneum in 26 (43.3％) cases,keratinocyte necrosis in the epidermis in 41 (68.3％) cases,generalized liquefactive degeneration in 30 (50.0％) cases,migration of lymphocytes into the epidermis in 43 (71.6％) cases,Pautrier's microabscess formation in 2 cases,varying degrees of extravasation of erythrocytes into the epidermis in 46 (76.7％) cases,fibrinoid necrosis of blood vessel walls in the dermis in 3 cases.PLEVA progressed into granuloma fungoides in 1 patient.Twenty patients underwent immunohistochemical examination,and 3 of them showed monoclonal hyperplasia of T cells.Conclusions PLEVA has characteristic clinical manifestations,and the combination of pathological and clinical examination is the gold standard for its diagnosis.
