Determination of plasma levels of interleukin-17 in patients with vitiligo
10.3760/cma.j.issn.0412-4030.2014.10.018
- VernacularTitle:白癜风患者血浆IL-17水平的检测
- Author:
Qing MIAO
;
Wei YU
;
Yanan CHENG
;
Mingyan JIA
;
Aiwu CHANG
- Publication Type:Journal Article
- Keywords:
Vitiligo;
Interleukin-17;
Immunity
- From:
Chinese Journal of Dermatology
2014;47(10):738-739
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between interleukin-17 (IL-17) and vitiligo.Methods Totally,32 vitiligo patients and 30 healthy human controls were enrolled in this study.Blood samples were collected from all the subjects,and enzyme-linked immunosorbent assay (ELISA) was performed to determine the plasma levels of IL-17.The relationship of plasma IL-17 levels with disease stage,clinical course and lesion area was assessed.Results The plasma levels of IL-17 were significantly higher in the patients with progressive and stable vitiligo than in the healthy controls (both P < 0.05),and higher in the patients with progressive vitiligo than in those with stable vitiligo (P < 0.05).Moreover,the plasma levels of IL-17 were positively correlated with the area of vitiligo lesions (r =0.456,P < 0.05),but unrelated to the clinical course of vitiligo (r =0.239,P > 0.05).Conclusion IL-17 may play a certain role in the occurrence and development of vitiligo.