Determination of plasma levels of interleukin-17 in patients with vitiligo

VernacularTitle:白癜风患者血浆IL-17水平的检测
Author: Qing MIAO ; Wei YU ; Yanan CHENG ; Mingyan JIA ; Aiwu CHANG
Publication Type:Journal Article
Keywords: Vitiligo; Interleukin-17; Immunity
From: Chinese Journal of Dermatology 2014;47(10):738-739
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between interleukin-17 (IL-17) and vitiligo.Methods Totally,32 vitiligo patients and 30 healthy human controls were enrolled in this study.Blood samples were collected from all the subjects,and enzyme-linked immunosorbent assay (ELISA) was performed to determine the plasma levels of IL-17.The relationship of plasma IL-17 levels with disease stage,clinical course and lesion area was assessed.Results The plasma levels of IL-17 were significantly higher in the patients with progressive and stable vitiligo than in the healthy controls (both P ＜ 0.05),and higher in the patients with progressive vitiligo than in those with stable vitiligo (P ＜ 0.05).Moreover,the plasma levels of IL-17 were positively correlated with the area of vitiligo lesions (r =0.456,P ＜ 0.05),but unrelated to the clinical course of vitiligo (r =0.239,P ＞ 0.05).Conclusion IL-17 may play a certain role in the occurrence and development of vitiligo.