Morphea complicated by Hashimoto's thyroiditis in two sisters
10.3760/cma.j.issn.0412-4030.2015.04.008
- VernacularTitle:姐妹同患硬斑病合并桥本甲状腺炎二例
- Author:
Jinpeng LIU
;
Xiaohong YU
;
Guoling YANG
;
Zhiqi SONG
- Publication Type:Journal Article
- Keywords:
Scleroderma,localized;
Lichen sclerosus et atrophicus;
Hashimoto disease;
Genetic predisposition to disease;
Case reports
- From:
Chinese Journal of Dermatology
2015;48(4):248-251
- CountryChina
- Language:Chinese
-
Abstract:
Morphea complicated by Hashimoto's thyroiditis is reported in two sisters.Case 1:a 64-year-old female presented with skin rashes on the anterior neck,trunk and bilateral anterior shins for 5 years,itching skin rashes on the perineum for 4 years,and Hashimoto's thyroiditis for 9 years.Physical examination revealed grade 1 enlargement of firm thyroid gland without exophthalmos or pretibial myxedema.Dermatological examination showed pink patches on the neck and breast,sclerosis and atrophy of skin over the back,porcelain-white patches on the perineum.Histopathological findings suggested the diagnosis of morphea on the breast and lichen sclerosus et atrophicus on the perineum.Case 2:a 55-year-old female,who was the younger sister of case 1,suffered from gradual sclerosis and atrophy of skin in the left inframammary region and abdominal region for 4 years,as well as Hashimoto's thyroiditis for 3 years.Similarly,physical examination revealed grade 1 enlargement of firm thyroid gland without exophthalmos or pretibial myxedema.Hypopigmentation,sclerosis and atrophy of skin were observed in the left inframammary region,abdominal region and central back region.Histopathological examination suggested a diagnosis of morphea.According to the clinical and histopathological manifestations,periodic acid-Schiff staining and thyroid gland function test results,the 2 cases were both diagnosed as morphea complicated by Hashimoto's thyroiditis.
