Inhibitory effect of 5-aminolevulinic acid photodynamic therapy on human papillomavirus replication in condyloma acuminatum lesions
10.3760/cma.j.issn.0412-4030.2014.10.019
- VernacularTitle:氨基酮戊酸光动力疗法治疗尖锐湿疣对病灶乳头瘤病毒复制的影响
- Author:
Hui WANG
;
Xueliang ZHAO
- Publication Type:Journal Article
- Keywords:
Condylomata acuminata;
Photochemotherapy;
Human papillomavirus
- From:
Chinese Journal of Dermatology
2014;47(10):739-741
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the changes in DNA loads of human papillomavirus (HPV) type 6/11 in lesions of patients with condyloma accuminatum (CA) before and after 5-aminolevulinic acid photodynamic therapy (ALA-PDT).Methods After removal of warts by electrocautery,HPV6/11-positive patients with CA were divided into two groups:treatment group (32 cases) receiving two sessions of ALA-PDT with intervals of 7-10 days,and control group (29 cases) remaining untreated.Exfoliated cells were collected from the lesional sites of these patients before and 3 months after the first session of ALA-PDT,and fluorescence-based quantitative PCR was conducted to estimate the DNA loads of HPV 6/11 in these cells.Results Three months after the first session of ALA-PDT,89.7％ (26/29) of the patients in the treatment group and 68.4％ (13/19) in the control group became HPV DNA negative,with significant differences between the treatment group and control group in the DNA loads of HPV ((1.70 ± 7.86) × 105 vs.(1.27 ± 2.21) × 106 copies/ml,P ＜ 0.05).Conclusion ALA-PDT can reduce HPV DNA loads in lesions of CA in patients.
