The relationship between serum asymmetric dimethylarginine and ABCD2 score in transient ischemic attack patients
10.3760/cma.j.issn.0578-1426.2014.11.008
- VernacularTitle:短暂性脑缺血发作患者血清非对称性二甲基精氨酸与ABCD2评分的相关性
- Author:
Yuanjin ZHANG
;
Dongsheng FAN
;
Nan ZHANG
- Publication Type:Journal Article
- Keywords:
Ischemic attack,transient;
Asymmetric dimethylarginine;
ABCD2 score
- From:
Chinese Journal of Internal Medicine
2014;53(11):876-879
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate relationships between serum asymmetric dimethylarginine (ADMA) and transient ischemic attack (TIA).Methods Forty hcalthy controls and 40 patients with TIA were enrolled in the present study.ABCD2 score was used to evaluate risk for future stroke.Serum ADMA levels were measured with ELISA analysis.Results Serum level of ADMA was higher in TIA group than that in control group [(0.52 ± 0.06) mmol/L vs (0.23 ± 0.04) mmol/L,P ＜ 0.05].In TIA subgroup,19 cases(47.5％)developed cerebral infarction and 23 cases(57.5％)had no stroke history.There is positive correlation between serum ADMA levels and ABCD2 score in both cerebral infarction subjects (r =0.560,P =0.013),and no stroke history cases(r =0.602,P =0.002).TIA subjects were,then,divided in to two groups based on ABCD2 score as 0-3 group and ≥ 4 group.In general linear model analysis,ADMA level was associated with ABCD2 score (F =4.39,P =0.043) after adjusted for age and gender.This situation hold true for subjects within cerebral infarction group (F =7.327,P =0.017) or non-previous stroke group(F =12.300,P =0.002).No association could bc found between ADMA level and ABCD2 score grouping in subjects with non-infarct (F =0.523,P =0.675) or stroke history (F =0.274,P =0.609).Conclusions Elevated ADMA is associated with occurrence of TIA.Endothelial dysfunction may play an important role in the pathogenesis of TIA.
