Pharmacokinetic profiles of lopinavir(LPV) in Chinese HIV-infected patients
10.3760/cma.j.issn.0578-1426.2015.05.011
- VernacularTitle:中国HIV感染者服用洛匹那韦药代动力学特点分析
- Author:
Xiaoying ZHANG
;
Zhengyin LIU
;
Xiaoli DU
;
Qiang FU
;
Taisheng LI
- Publication Type:Journal Article
- Keywords:
HIV;
Pharmacokinetics;
Lopinavir
- From:
Chinese Journal of Internal Medicine
2015;54(5):431-433
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the pharmacokinetic profiles of lopinavir(LPV) in Chinese HIV-infected patients.Methods A total of 16 patients were enrolled in the LPV pharmacokinetic study.Blood samples were collected before LPV intake and 0.5,1.0,1.5,2.0,2.5,3.0,4.0,6.0,8.0,10.0,12.0 h after administration.Serum level of LPV was determined by the developed high performance liquid chromatography (HPLC) method.The pharmacokinetic profiles were assessed by WinNonlin software.Results The non-compartment model pharmacokinetic (PK) parameters were as follows:the peak time of LPV (Tmax) (3.88 ± 0.23) h,maximum plasma concentration (Cmax) (10.36 ± 3.42) mg/L,minimum plasma concentration (Cmin) (2.18 ± 0.34) mg/L,the 24 h area under plasma-concentration-time curve (AUC0-24) (116.22 ± 15.68) mg · h · L-1,half life(T1/2) (4.5 ± 0.13) h,and clearance rate (CL/F) (3.44 ± 1.34) L/h respectively.Conclusions The pharmacokinetic profiles of LPV in Chinese HIV-1 infected patients demonstrate lower Cmin than those of reported studies,while other parameters are similar.Patients should be educated for compliance based on the narrow gap between Cmin and minimum effect concentration.
