The association between angiogenin gene variations and familial amyotrophic lateral sclerosis in Chinese Han patients
10.3760/cma.j.issn.0578-1426.2015.02.008
- VernacularTitle:血管生长素基因突变与中国汉族家族性肌萎缩侧索硬化的关系
- Author:
Huagang ZHANG
;
Yingshuang ZHANG
;
Lu TANG
;
Nan ZHANG
;
Dongsheng FAN
- Publication Type:Journal Article
- Keywords:
Amyotrophic lateral sclerosis,familial;
DNA mutational analysis;
Polymorphism,single nucleotide;
Angiogenins
- From:
Chinese Journal of Internal Medicine
2015;54(2):122-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of genetic variants in angiogenin (ANG) on the susceptibility of familial amyotrophic lateral sclerosis (FALS) in Han Chinese.Methods Thirty-one FALS families from 2009 to 2012 were collected and ANG gene was screened in the probands using PCR and direct sequencing.Results All 31 ALS families were autosomal dominant inheritance.No mutations and single nucleotide polymorphism were detectable in ANG gene in the 31 probands.Conclusion Our study suggests that ANG gene variations may be rare in Chinese Han FALS.
