A multicenter study of correlation between peripheral lymphocyte counts and CD4+ T cell counts in HIV/AIDS patients
10.3760/cma.j.issn.0578-1426.2015.02.007
- VernacularTitle:HIV/AIDS患者外周血CD4+ T细胞计数和淋巴细胞计数相关性的多中心研究
- Author:
Jing XIE
;
Zhifeng QIU
;
Yang HAN
;
Yanling LI
;
Xiaojing SONG
;
Taisheng LI
- Publication Type:Journal Article
- Keywords:
HIV;
Acquired immunodeficiency syndrome;
CD4+ T cell;
Lymphocyte count
- From:
Chinese Journal of Internal Medicine
2015;54(2):118-121
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the accuracy of lymphocyte count as a surrogate for CD4+T cell count in treatment-na(i)ve HIV-infected adults.Methods A total of 2 013 HIV-infected patients were screened at 23 sites in China.CD4+ T cell counts were measured by flow cytometry.Correlation between CD4+ T cell count and peripheral lymphocyte count were analyzed by spearman coefficient.AUCRoc were used to evaluate the performance of lymphocyte count as a surrogate for CD4+ T cell count.Results The lymphocyte count and CD4+T cell count of these 2 013 patients were (1 600±670) × 106/L and (244 ± 148) × 106/L respectively.CDa+ T cell count were positively correlated with lymphocyte count(r =0.482,P ＜0.000 1).AUCROC of lymphocyte count as a surrogate for CD4+ T cell counts of ＜ 100 × 106/L,＜200 × 106/L and ＜ 350 × 106/L were 0.790 (95％ CI 0.761-0.818,P ＜ 0.000 1),0.733 (95％ CI 0.710-0.755,P ＜ 0.000 1) and 0.732 (95％ CI 0.706-0.758,P ＜ 0.000 1) respectively.Conclusion Lymphocyte count could be considerad as a potential surrogate marker for CD4+ T cell count in HIV/AIDS patients not having access to T cell subset test by flowcytometry.
