Effects of active and passive smoking on chronic kidney disease in patients with type 2 diabetes mellitus
10.3760/cma.j.issn.0578-1426.2014.11.005
- VernacularTitle:主动吸烟、被动吸烟与2型糖尿病伴慢性肾脏病的关系
- Author:
Fei JIANG
;
Miao CHEN
;
Cheng HU
;
Yuqian BAO
;
Weiping JIA
- Publication Type:Journal Article
- Keywords:
Smoking;
Diabetes mellitus,type 2;
Glomerular filtration rate;
Albuminuria
- From:
Chinese Journal of Internal Medicine
2014;53(11):858-864
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study aimed to assess the effects of active and passive smoking on chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM).Methods Seven hundred and five patients with T2DM were recruited in the study and were divided into three groups based on smoking status as active smokers,passive smokers and non-smokers.Twenty-four hour urinary albumin excretion (24hUAE) was measured,and estimate glomerular filtration rate (eGFR) was calculated with age and blood creatinine levels.Results (1) The proportion of CKD in T2DM in the present study was 31.63％ (223/705) with 28.6％ (22/77),30.0％ (15/50) and 29.6％ (73/247) for non-smokers,passive smokers and active smokers in men,and 29.9％ (40/134),35.9％ (66/184) and 7/13 for non-smokers,passive smokers and active smokers in women,respectively.In comparison with non-smokers,a higher risk of CKD was found in both passive and active smokers (OR =1.07 and OR =1.05 in men ; OR =1.31 and OR =2.74 in women,respectively).(2) Compared with non-smokers,passive smokers had a significant higher risk for albuminuria in women (OR =2.02,P =0.016).(3) After adjusting for gender,age,duration of T2DM,BMI,systolic blood pressure,glycosylated hemoglobin A1C and lipids,there was a significant decrease in eGFR between active and never smokers (P =0.018)or passive smokers (P =0.000) in women.No differences could be found in eGFR between each smoking statues in men.Conclusions Smoking exposure alone confers a high risk for CKD in patients with T2DM.Our results highlight an importance in implementation of a smoke-free environment for patients with T2DM.
