Research progress in Smad1 and diabetic nephropathy
10.3760/cma.j.issn.1000-6699.2015.05.020
- VernacularTitle:Smad1与糖尿病肾病的研究进展
- Author:
Ying ZHOU
;
Xianxian CHEN
;
Lie FENG
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
Smad1 protein;
Mesangial matrix expension
- From:
Chinese Journal of Endocrinology and Metabolism
2015;31(5):468-470
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic nephropapthy (DN) is a common cause of end-stage renal disease.Early diagnosis and treatment are significant for delaying the development of DN.Smad proteins mediate transforming growth factor β superfamily intracellular signal transduction.Recent studies have found that Smad1 protein plays an important role in the process of renal fibrosis.Urine Smad1 emerges in the early stage of DN,which is expected to be a non-invasive indicator in early diagnosis of DN.
