Update on the relationship between testicular function and bone metabolism
10.3760/cma.j.issn.1000-6699.2015.04.020
- VernacularTitle:睾丸功能与骨代谢关系的研究进展
- Author:
Guofang CHEN
;
Chao LIU
- Publication Type:Journal Article
- Keywords:
Testosterone;
Insulin-like 3;
Cytochrome P450 2R1;
Bone metabolism
- From:
Chinese Journal of Endocrinology and Metabolism
2015;31(4):372-374
- CountryChina
- Language:Chinese
-
Abstract:
It has been well known that testosterone is the only connection between testis and bone as it plays an important role in skeletal growth and bone mass accrual.In the past few years,studies showed that factors other than testosterone could also be responsible for bone health.The Leydig cells in the testis produce insulin-like 3 and express cytochrome P450 2R1 (CYP2R1) gene which encodes the major enzyme involved in 25-hydroxylation of vitamin D.The understanding of the crosstalk between testis and bone could contribute to defining an improved clinical approach to the biochemical diagnosis and therapeutic management of hypogonadism and male osteoporosis.
