Bicyclol versus diammonium glycyrrhizinate for the treatment of drug-induced hepatic injury in patients with severe psoriasis: a randomized controlled trial
10.3760/cma.j.issn.0412-4030.2015.04.007
- VernacularTitle:双环醇和甘草酸二铵治疗严重银屑病患者药物性肝损伤的随机对照研究
- Author:
Xiaoyong ZHOU
;
Xueyuan YANG
;
Yunyun SUN
;
Xinyu LI
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Drug-induced liver injury;
Therapies,investigational;
Bicyclol;
Diammonium glycyrrhizinate
- From:
Chinese Journal of Dermatology
2015;48(4):245-247
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of bicyclol tablets on drug-induced hepatic injury in patients with severe psoriasis.Methods One hundred and six patients with severe psoriasis and drug-induced hepatic injury were enrolled in this study,and randomly divided into 2 groups:bicyclol group (53 cases) treated with oral bicyclol tablets (25 mg thrice a day) for 8 weeks,diammonium glycyrrhizinate group (53 cases) treated with diammonium glycyrrhizinate capsules (150 mg thrice a day) for 8 weeks.Serum biochemical indices of hepatic function were measured before and after treatment,therapeutic efficacy was evaluated,and adverse reactions were observed and recorded after treatment.Intergroup and intragroup differences in these parameters were assessed.Results During the treatment,3 patients were lost to follow up.After treatment,serum biochemical indices of hepatic function markedly improved in both the bicyclol group (52 cases) and diammonium glycyrrhizinate group (51 cases) (both P ＜ 0.01),and the bicyclol group showed a better treatment response than the diammonium glycyrrhizinate group (P ＜ 0.01).The marked response rate was 71.15％ and 47.06％ (P ＜ 0.05),and the response rate was 84.62％ and 66.67％ (P ＜ 0.05),respectively,in the bicyclol group and diammonium glycyrrhizinate group.No adverse reactions related to tested drugs were observed in either of the two groups.Conclusion Bicyclol can attenuate antipsoriatic drug-induced hepatic injury with good safety.
