Green tea extract improves the lipid metabolism in patients with metabolic syndrome: a meta-analysis
10.3760/cma.j.issn.1000-6699.2015.03.007
- VernacularTitle:绿茶提取物改善代谢综合征患者脂质代谢的meta分析
- Author:
Xiumin LI
;
Huanghui WU
;
Yuan XIAO
;
Xiaoming WANG
- Publication Type:Journal Article
- Keywords:
Green tea extract;
Metabolic syndrome;
Lipid metabolism;
Meta-analysis;
Randomized controlled trial
- From:
Chinese Journal of Endocrinology and Metabolism
2015;31(3):224-229
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the efficacy and safety of green tea extract (GTE) in improving lipid metabolism in patients with metabolic syndrome (MS).Methods All relevant published articles in Chinese and English literature database were searched to collect the randomized controlled trials comparing the efficiency and safety of GTE in patients with MS.The meta-analysis was performed using RevMan 5.2 software.Results Nine studies involving 566 patients were included.The results of recta-analysis showed that:GTE significantly reduced the level of low-density lipoprotein cholesterol (LDL-C) (SMD =-0.33,95％ CI-0.56 ～ -0.09,P=0.007)compared with placebo at the treatment endpoint.There were no statistical significance in high-density lipoprotein cholesterol (SMD =0.19,95 ％ CI-0.04 ～ 0.43,P =0.10),total cholesterol (SMD =-0.13,95％ CI-0.39 ～ 0.13,P =0.33),and triglyceride (SMD =-0.07,95％ CI-0.46 ～ 0.33,P =0.74) levels between two groups.There was no significant difference in the overall rate of adverse events between two groups (OR =0.97,95 ％ CI 0.54 ～ 1.76,P =0.93).Conclusion GTE significantly reduces the level of LDL-C in patients with MS,and the adverse events were rare and mild.
