Relationship between diabetes and betatrophin
10.3760/cma.j.issn.1000-6699.2014.12.002
- VernacularTitle:糖尿病与Betatrophin
- Author:
Guoyue YUAN
;
Hao HU
;
Wenjun SUN
;
Libin ZHOU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Betatrophin
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(12):1041-1043
- CountryChina
- Language:Chinese
-
Abstract:
Replenishing the insulin-producing β cell mass is considered to be a hot topic in the field of diabetes treatment.It has long been known that pancreatic β cells are generated primarily by self-duplication in adults.However,insulin resistance can induce dramatic compensatory β cell mass expansion in the pancreas.Therefore,it is of great value to investigate the etiology and pathogenesis of β cell proliferation under insulin resistance.The recent study has shown that betatrophin,a protein secreted by the liver,modulates β cell growth in response to insulin resistance.We published one article in Diabetes Care titledIncreased circulating levels of betatrophin in newly diagnosed type 2 diabetic patientsto elaborate the relationship between diabetes and betatrophin.
