Research progress in parathyroid hormone-related protein and diabetic nephropathy
10.3760/cma.j.issn.1000-6699.2014.11.015
- VernacularTitle:甲状旁腺激素相关蛋白在糖尿病肾病中的研究进展
- Author:
Zhen ZHU
;
Li WEI
- Publication Type:Journal Article
- Keywords:
Cell cycle regulatory protein;
Diabetic nephropathy;
Angiotensin Ⅱ
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(11):1009-1011
- CountryChina
- Language:Chinese
-
Abstract:
Parathyroid hormone-related protein (PTHrP) and its receptor type 1 (PTH1 R) are extensively expressed in the kidney,where they are able to modulate renal function.Animal and human studies have shown that PTHrP acts as an important mediator of diabetic renal cell hypertrophy by a meehanism which involves the modulation of cell cycle regulatory proteins and TGF-β1.Furthermore,angiotensin Ⅱ (Ang Ⅱ) appears to be responsible for PTHrP upregulation in these conditions.These findings provide novel insights into the well-known protective effects of Ang Ⅱ antagonists in renal diseases,paving the wav for new therapeutic approaches.
