Anti-inflammatory cytokines and type 2 diabetes
10.3760/cma.j.issn.1000-6699.2015.04.021
- VernacularTitle:抗炎因子与2型糖尿病
- Author:
Yueming LIU
;
Zhen YANG
;
Qing SU
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory cytokines;
Inflammatory;
Diabetic mellitus,type 2
- From:
Chinese Journal of Endocrinology and Metabolism
2015;31(4):375-378
- CountryChina
- Language:Chinese
-
Abstract:
Compared with proinflammatory processes in the development of type 2 diabetes,our knowledge on anti-inflammatory cytokines is rather limited.Anti-inflammatory cytokines such as adiponectin,interleukin 1 receptor antagonist(IL-1RA),transforming growth factor-β1 (TGF-β1),growth differentiation factor-15 (GDF-15),omentin,and secreted frizzled-related protein 5 (SFRP5) are strongly associated with increased risk of type 2 diabetes:Adiponectin and omentin levels decreased before type 2 diabetes,in contrast,concentrations of IL-1RA,TGF-β1,GDF-15 are increased.Change of SFRP5 levels in impaired glucose tolerance and type 2 diabetes remains controversial.This paper will summarize and recommend studies that investigated associations between circulating levels of anti-inflammatory cytokines and type 2 diabetes.
