Changes in endothelial function in rats with subclinical hypothyroidism after levothyroxine treatment
10.3760/cma.j.issn.1000-6699.2015.04.016
- VernacularTitle:左旋甲状腺素替代治疗对亚临床甲状腺功能减退大鼠内皮功能的影响
- Author:
Limin TIAN
;
Tingting LI
;
Cuixia GAO
;
Jing LIU
;
Qian GUO
- Publication Type:Journal Article
- Keywords:
Subclinical hypothyroidism;
Rat;
Levothyroxine;
Hemodynamics;
Endothelium
- From:
Chinese Journal of Endocrinology and Metabolism
2015;31(4):360-362
- CountryChina
- Language:Chinese
-
Abstract:
Established rat models with subclinical hypothyroidism (SCH) were divided into three groups:subclinical hypothyroid(SCH),SCH treated with levothyroxine (L-T4),and control group.The L-T4 group displayed lowered total cholesterol and endothelin levels compared with the SCH group[(1.29 ±0.05 vs 2.38 ±0.55) mmol/L,(98.54 ± 32.43 vs 160.62 ±37.25) nmol/L,both P＜0.05].Nitric oxide levels,left ventricular systolic pressure,and blood flow in abdominal aorta were significantly higher in the L-T4 group than those in the SCH group.The results of this study indicate that L-T4 treatment may improve endothclial dysfunction and hemodynamic changes in rats with SCH.
