Effect of calcitriol on subclinical macrovascular disease in type 2 diabetic patients

VernacularTitle:骨化三醇治疗对2型糖尿病亚临床大血管病变的影响
Author: Ruihua CHEN ; Xiaozhen JIANG ; Zhe GU ; Yuan ZHANG ; Peili GU ; Bin ZHOU
Publication Type:Journal Article
Keywords: Diabetes mellitus,type 2; Subclinical macrovascular disease; Calcitriol; Carotid intima media thickness
From: Chinese Journal of Endocrinology and Metabolism 2015;31(3):251-253
CountryChina
Language:Chinese
Abstract: The changes of carotid intima media thickness (cIMT) in type 2 diabetic patients with vitamin D insufficiency and subclinical macrovascular disease after 12 months' intervention therapy with calcitriol were observed.86 patients with vitamin D insufficiency [25 (OH) D＜30 ng/ml] and subclinical macrovascular disease were randomized to group A (n =44,treated with 0.5 μg/day calcitriol) or group B (n =42,blank control) for 12 months.40 patients in each group completed the follow up.After 12 months of therapy with calcitriol (0.5 μg.qd.po.),levels of high sensitive-Creactive protein,sCD36,and cIMT were significantly decreased,while 25 (OH) D and ankle brachial index were significantly increased (P＜0.05) in group A,suggesting that calcitriol could improve cIMT in patients with vitamin D insufficiency and subclinical macrovascular disease.