Research progress in the regulation of epigenetics on pancreatic β cell function

VernacularTitle:表观遗传调控在胰岛β细胞功能调控中的研究进展
Author: Jing SU ; Junling LIU ; Xiaoying DING
Publication Type:Journal Article
Keywords: Diabetes mellitus,type 2; Epigenetics; Pancreatic β cell
From: Chinese Journal of Endocrinology and Metabolism 2015;31(1):78-82
CountryChina
Language:Chinese
Abstract: [Summary] Epigenetics defines heritable changes in gene expression that are not coded in the DNA sequence itself.Three systems,including DNA methylation,RNA-associated silencing and histone modification,are used to initiate and sustain epigenetic silencing.Type 2 diabetes mellitus(T2DM) is a polygenic disorder,which is caused by both genetic and environmental factors.However,pathogenesis of T2DM has not been elucidated.Recent studies have indicated that epigenetics may play an important role in the pathogenesis of T2DM,which is involved in the development and differentiation of β cell,secretion of β cell,insulin sensitivity and so on.Researches related to epigenetics may provide a new measure and target to clarify the pathogenesis of T2DM as well as prevent and treat the disease.