S100 calcium binding protein A4 expression and signiifcance in gastric cancer
10.3969/j.issn.1007-3969.2015.06.004
- VernacularTitle:S100钙结合蛋白A4在胃癌组织中的表达及意义
- Author:
Tianbiao ZHANG
;
Wenhui SU
;
Ying ZHAO
;
Xinying CHEN
- Publication Type:Journal Article
- Keywords:
S100 calcium-binding protein A4;
Gastric cancer;
Immunohistochemistry;
RT-PCR;
Western blot
- From:
China Oncology
2015;(6):423-431
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:This study investigated the relationship between (S100 calcium-binding protein A4, S100A4) in chronic gastritis, intestinal metaplasia, dysplasia adenomatous, normal tissue tissue samples and expression in gastric cancer and clinical characteristics. Methods:HE staining of the use of gastric specimens taken for histopathological diagnosis;using immunohistochemistry to detect the expression of tissue S100A4 protein;qRT-PCR was used to detect mRNA expression of S100A4 gene;Western Blot detection of S100A4 gene encoding protein. Kaplan-Meier survival curves were used to distinguish and compare survival. Results:S100A4 protein and mRNA expression gradually increased in the following order:normal tissue
