Chinese medicine intervention for steroid-induced necrosis of the femoral head：from basic study to clinical application
10.3969/j.issn.2095-4344.2015.29.026
- VernacularTitle:中药干预修复激素性股骨头坏死：基础实验与临床应用转化的距离？
- Author:
Zhengxin ZHOU
- Publication Type:Journal Article
- Keywords:
femur head necrosis;
hormones;
drugs,Chinese herbal
- From:
Chinese Journal of Tissue Engineering Research
2015;(29):4726-4730
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Chinese herbal medicine for treatment of steroid-induced necrosis of the femoral head has been shown to be effective, but its mechanism remains controversial. OBJECTIVE:To retrieve and summarize the mechanism of Chinese herbal medicine for steroid-induced necrosis of the femoral head in recent 10 years. METHODS:We retrieved articles addressing the mechanism of Chinese herbal medicine for intervention of steroid-induced necrosis of the femoral head in China National Knowledge Infrastructure published from January 2005 to December 2014. The key words were femur head necrosis, hormones, drugs, and Chinese herbal. According to inclusion and exclusion criteria, 23 articles were selected for discussion. RESULTS AND CONCLUSION:Studies concerning the mechanism of Chinese medicine for steroid-induced necrosis of the femoral head mainly focus on lowering blood lipid and anticoagulation, improving blood rheology, reducing intraosseous pressure, promoting angiogenesis and inhibiting apoptosis, as wel as cytokines and related factors. This study mainly concerns classical formulae, empirical prescription and various Chinese patent medicines, but does not address differentiation of symptoms and signs for classification of syndrome, diagnosis and treatment based on an overal analysis of the ilness and the patient’s condition, targeted rule of treatment, and prescription drugs.
