Expression of Delta-catenin protein in breast invasive ductal carcinoma and relationship between ;its expression and prognosis of patients
10.3969/j.issn.1007-3969.2015.06.002
- VernacularTitle:Delta-catenin蛋白在乳腺浸润性导管癌中的表达及其与患者预后的关系
- Author:
Lihong SUN
;
Huiqing KANG
;
Xia WANG
;
Haiyan KANG
;
Jian ZHANG
;
Zhiqiang YANG
;
Hongquan WANG
;
Chaojun ZHANG
;
Junyi ZHANG
- Publication Type:Journal Article
- Keywords:
Delta-catenin;
Breast cancer;
Prognosis
- From:China Oncology
2015;(6):408-414
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose: As a member of Catenin family, little is known about expressive signiifcance and mechanism of Delta-catenin in numerous tumors. In present study, we investigated the expression of Delta-catenin in breast cancer tissues and its correlation with the prognosis of patients. Methods:We examined the expression of Delta-catenin and its correlation with clinicopathological factors of patients by immunohistochemistry in 92 cases of breast cancer tissues with tissue micro-array. The mRNA and protein expression of Delta-catenin were also detected in another 32 cases of frozen paired breast cancer tissues and normal breast tissues. Results:Compared with normal breast tissues, the mRNA and protein expression of Delta-catenin were increased in breast cancer tissues, and expression of Delta-catenin was closely associated with histological grade and lymph node metastasis (P=0.016 and 0.022, respectively). Moreover, Kaplan-Meier survival analysis revealed that patients with high Delta-catenin expression had shorter survival than patients with low expression (P=0.015), and multivariate Cox analysis revealed that high Delta-catenin expression was also an independent prognostic factor (P=0.017). Conclusion:Our results suggest that Delta-catenin acts as an oncoprotein when overexpressed in breast cancer, and its expression is associated with poor prognosis of patients.
