Advances in Study on Toll-like Receptors and its Gene Polymorphisms in Gastric Mucosal Diseases
10.3969/j.issn.1008-7125.2015.07.012
- VernacularTitle:ToII 样受体及其基因多态性与胃黏膜疾病相关性的研究进展
- Author:
Jing LI
;
Xiangjun JIANG
- Publication Type:Journal Article
- Keywords:
Toll-Like Receptors;
Polymorphism,Single Nucleotide;
Gastric Mucosa;
Helicobacter pylori
- From:
Chinese Journal of Gastroenterology
2015;(7):431-434
- CountryChina
- Language:Chinese
-
Abstract:
The development and progress of gastric mucosal diseases is a complex process associated with multiple factors and underlying mechanisms,and individuals may present different genetic susceptibilities to gastric mucosal diseases. Various studies have demonstrated a strong link between Toll-like receptors( TLRs),as pattern recognition receptors,and the development and progress of gastric mucosal diseases. The gene polymorphisms of TLRs may change its encoded proteins or related signaling pathways,which results in different susceptibilities to gastric mucosal diseases;this might affect the development,progress and clinical outcome of the disease. In this review article,the advances in study on TLRs and its gene polymorphisms in gastric mucosal diseases were summarized.
