Vascular endothelial growth factor and hypoxia-inducible factor suppress chondrocyte apoptosis

VernacularTitle:血管内皮生长因子和缺氧诱导因子对软骨细胞凋亡的作用
Author: Jianlin ZHOU ; Hongsong FANG ; Hao PENG ; Shuang DENG ; Jinqing WENG ; Feng LIU ; Sen CHEN ; Guanjin ZHOU
Publication Type:Journal Article
Keywords: Vascular Endothelial Growth Factors; Hypoxia-Inducible Factor 1; Chondrocytes; Apoptosis
From: Chinese Journal of Tissue Engineering Research 2015;(29):4705-4709
CountryChina
Language:Chinese
Abstract: BACKGROUND:Osteoarthritis is a joint disease that primarily affects the cartilage. With the changes of the extracelular matrix, chondrocytes appear to have apoptosis. Vascular endothelial growth factor plays an important role in promoting endothelial cel division and proliferation and inducing angiogenesis. Hypoxia-inducible factor is a celular transcription factor and produces different reactions due to the oxygen content. Vascular endothelial growth factor and hypoxia-inducible factor are focused on inhibiting chondrocyte apoptosis. OBJECTIVE:To elaborate the effects of vascular endothelial growth factor and hypoxia-inducible factors on chondrocyte apoptosis. METHODS: Recent literatures related to chondrocyte apoptosis were summarized and analyzed. During the process of osteoarthritis, changes in vascular endothelial growth factors in chondrocytes and regulatory effects of vascular endothelial growth factor and hypoxia-inducible factor on chondrocyte apoptosis were elaborated.