Research progress of treatment and therapeutic target for Luminal B breast cancer
10.3969/j.issn.1007-3969.2015.07.011
- VernacularTitle:Luminal B型乳腺癌的治疗及其靶点的研究进展
- Author:
Yunpo SUN
;
Xuexiang YING
;
Pingqing HE
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Luminal B subtype;
Treatment;
Target
- From:
China Oncology
2015;(7):555-560
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer can be classiifed into 4 intrinsic subtypes by gene expression proifling: basal-like, HER-2-positive, Luminal A and Luminal B. Although Luminal cancers share similarities, the studies showed that Lu-minal A and B breast cancers should be perceived as distinct entities. Luminal B breast cancer has lower expression of hormone receptors, and it also exhibits worse prognosis and has a distinct proifle of response to chemotherapy and en-docrine therapy. This review presented the available clinical evidence for chemotherapy and endocrine therapy patterns of response, and potential targets for treatment.
