Research and clinical applications regarding endothelial progenitor cell transplantation
10.11817/j.issn.1672-7347.2014.11.018
- VernacularTitle:内皮祖细胞移植治疗的研究进展和临床应用前景
- Author:
Kefang TAN
;
Xuan SUN
- Publication Type:Journal Article
- Keywords:
endothelial progenitor cells;
biological characteristics;
transplantation therapy;
clinical application
- From:
Journal of Central South University(Medical Sciences)
2014;(11):1211-1216
- CountryChina
- Language:Chinese
-
Abstract:
Endothelial injury or dysfunction leads to multiple cardiovascular diseases, such as atherosclerosis, myocardial infarction, stroke, hypertension and peripheral vascular disease. Endothelial progenitor cells (EPCs) are precursor cells of endothelial cells, including the early endothelial progenitor cells and the late endothelial progenitor cells. hTese two EPC types have different function and surface markers. EPC in this article mainly means late endothelial progenitors which could grow into endothelial cloning and form vessels in vivo. Late EPCs can express CD133, CD31, KDR, CD144, CD34 etc, take in low density lipoprotein, bind with ulex europaeus lectin 1 and form blood vessels in vitro and in vivo. EPCs not only participate in new blood vessels formation, but also are closely related to the repair of damaged endothelium. Many studies conifrm that the transplanted EPCs are able to be mobilized to vascular injury location and repair the damaged endothelial cells thus promote new blood vessel formation, which provides a promising strategy for the treatment ofcardiovascular diseases and ischemic diseases.
