Relationship between FOX family genes and leukemia
10.3760/cma.j.issn.1673-4408.2015.04.010
- VernacularTitle:FOX基因与白血病相关性研究进展
- Author:
Yingjie YI
;
Xiuhong JIA
- Publication Type:Journal Article
- Keywords:
Leukemia;
FOXO3a;
FOXM1;
FOXP3
- From:
International Journal of Pediatrics
2015;(4):397-399
- CountryChina
- Language:Chinese
-
Abstract:
FOX genes code transcription factors. FOXO3a,FOXM1,FOXP3 are members of FOX genes family,which are associated with leukemia. Phosphorylated FOXO3a which loses the function of suppressing leu-kemia is inactive. Phosphorylated FOXO3a expresses in leukemic cell cytoplasm. FOXM1 is an oncogenesis tran-scription factor. FOXM1 highly expresses in myeloid leukemic cells. Expression of FOXP3 in leukemic cells has diversity. FOXP3 mainly expresses in T cell leukemic cells. These genes abrrant expressions play a key role in leukemia pathogenesis,development,therapy,drug resistance and prognosis.
