Genetic studies of short stature
10.3760/cma.j.issn.1673-4408.2015.04.011
- VernacularTitle:身材矮小相关基因研究进展
- Author:
Wenxia SHEN
;
Chaochun ZOU
- Publication Type:Journal Article
- Keywords:
Short stature;
Gene;
Genetics
- From:
International Journal of Pediatrics
2015;(4):400-404
- CountryChina
- Language:Chinese
-
Abstract:
Human height is mainly regulated by the hypothalamus-pituitary-growth hormone axis, and also affected by other factors,such as nutrition and physical activity. Genetic factor is thought to be the main fac-tor,and genetic degree is about 80%. At present,genetic analysis in short stature has made great progresses both at home and abroad,and genes related to the height are more than 180. The article reviews some of the major genes related to the short stature,including the genes related to the adenohypophysis development,the genes re-lated to the GHRH-GH-IGF1 axis,as well as other related gene mutations and performance.
