Effect of early goal directed therapy on tissue perfusion and oxygen metabolism in patients with septic shock
10.3760/cma.j.issn.1673-4904.2014.22.017
- VernacularTitle:感染性休克患者应用早期目标导向治疗对组织微循环及氧代谢的影响分析
- Author:
Songmei LIN
;
Yuming GAO
;
Guoqing ZHOU
- Publication Type:Journal Article
- Keywords:
Microcirculation;
Septic shock;
Early goal directed therapy;
Tissue perfusion;
Tissue oxygenation
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(22):55-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of early goal directed therapy (EGDT) on tissue perfusion,microcirculation and oxygen metabolism in patients with septic shock.Methods A prospective observational study was carried out in 69 patients with early septic shock within 24 hours.The eligible patients were treated with the standard procedure of EGDT.The partial pressure of transcutaneous oxygen (PtcO2) and transcutaneous carbon dioxide (PtcCO2) was monitored and the changes of hemodynamic data,tissue oxygen,microcirculation before and after reaching the criteria of EGDT were recorded.Results Compared with that before treatment,PtcO2,tissue oxygenation index (PtcO2/FiO2) after EGDT was increased [(78.1 ± 30.8) mmHg (1 mmHg =0.133 kPa) vs.(62.8 ± 24.1) mmHg and (141.7 ± 78.3) mmHg vs.(110.8 ± 60.5) mmHg],PtcCO2 and percutaneous arterial carbon dioxide partial pressure difference was decreased[(29.0 ±4.1) mmHg vs.(39.1 ±6.4) mmHg and (1.4 ±0.5) mmHg vs.(1.7 ±0.8) mmHg],there was significant difference(P＜ 0.05).There was no significant difference in PtcO2,PtcO2/FiO2,PtcCO2,central venous blood oxygen saturation,lactic acid,oxygen and oxygen consumption (P ＞ 0.05).Conclusion EGDT can improve local tissue perfusion and microcirculation in patients with septic shock,body tissue perfusion index before and after EGDT may not be able to reflect the local tissue perfusion.
