Effect of tiotropium bromide on pulmonary function and airway remodeling in elder chronic obstructive pulmonary disease stabilization patients
10.3760/cma.j.issn.1673-4904.2014.22.015
- VernacularTitle:噻托溴铵对老年慢性阻塞性肺疾病稳定期患者肺功能及气道重塑的影响
- Author:
Feng GONG
- Publication Type:Journal Article
- Keywords:
Pulmonary disease;
chronic obstructive;
Airway remodeling;
Respiratory function tests;
Tiotropium bromide
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(22):48-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effect of tiotropium bromide on pulmonary function and airway remodeling in elder chronic obstructive pulmonary disease (COPD) stabilization patients.Methods Ninety-two elder patients diagnosed as COPD stabilization were divided into treatment group (50 patients) and control group (42 patients) by random digits table method.The patients in two groups were given basic treatment such as antimicrobial therapy,spasmolysis,antiasthma,expelling phlegm,and the patients in treatment group were given tiotropium bromide every day for 12 months besides the basic treatment.Meanwhile,40 healthy persons whose ages matched with those of COPD stabilization patients were as healthy control group.High resolution computerized tomography (HRCT) was employed to measure the parameters such as the airway wall thickness,the outer and inner diameter of the airway,airway wall area to assessed the airway remodeling before and after treatment in order to evaluate the drug etficacy.Meanwhile,the lung function,the inflammatory cytokines [interleukin (IL)-8,tumor necrosis factor (TNF)-α] in blood plasma and T lymphocyte subsets were also determined.Results The index of lung function in treatment group was significantly better than that before treatment and control group,and there was significant difference (P ＜ 0.05).The airway wall thickness in treatment group had no significant difference before and after treatment (P ＞0.05),and other index of airway remodeling was significantly improved compared with that before treatment (P ＜ 0.05).After treatment,the distance of 6 min walk test in treatment group was significantly longer than that in control group,and there was significant difference (P ＜ 0.05).The level of serum IL-8 and TNF-αt before treatment had no significant difference between two groups (P ＞0.05),and decreased significantly after treatment and the improvement was more pronounced in treatment group compared with that in control group (P ＜ 0.05).Compared with that in healthy control group,the level of CD3+,CD4+,CD4+/CD8+ was significantly lower and the level of CD8+ was significantly higher before treatment in treatment group and control group (P ＜ 0.05).After treatment,the level of CD3+,CD4+,CD4+/CD8+ was significantly increased and the level of CD8+ was significantly decreased (P ＜ 0.05),and the improvement was more pronounced in treatment group compared with that in control group (P ＜ 0.05).Conclusion Tiotropium bromide can improve airway remodeling and lung function in elder COPD stabilization patients.
