Inactivation of Nrf2 Decreases Load-driven Bone Formation
- VernacularTitle:Nrf2的失活对应力负荷下的骨形成的影响
- Author:
Yang YANG
;
Aihua XU
;
Qi DAI
;
Jiaxing ZHANG
;
Yongxin SUN
- Publication Type:Journal Article
- Keywords:
Nrf2;
loading-driven;
bone formation
- From:
Journal of China Medical University
2015;(6):513-515
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of nuclear factor(erythroid?derived 2)?like 2(Nrf2)in load?driven bone metabolism in Nrf2 knock?out(KO)mice. Methods The hybridized mice in the same brood were selected through PCR detection and were divided into two groups,i.e.,the Nrf2 knockout(KO)group and the wild?type(WT)group. Ulna of mice was loaded with 4 000 peak microstrains at 2 Hz for 3 consecutive days (120 cycles/day)as scheduled,the relative mineralizing surface(rMS/BS)and the relative bone formation rate(rBFR/BS)of ulna were measured for the two groups. Results Load?induced bone formation was suppressed in KO mice. Compared to the WT control,the relative bone formation rate was roughly 84%lower in KO mice(P<0.01). Conclusion The loss?of?function mutation of Nrf2 in bone diminishes load?driven bone formation.
