Progress of the test and assessment of islet β cell function
10.3760/cma.j.issn.1673-4408.2015.04.006
- VernacularTitle:胰岛β细胞功能检测及评价方法的新进展
- Author:
Guohua LI
;
Junfen FU
;
Guanping DONG
- Publication Type:Journal Article
- Keywords:
Islet β cell function;
Functional detection and assessment;
Diabetes
- From:
International Journal of Pediatrics
2015;(4):381-384
- CountryChina
- Language:Chinese
-
Abstract:
Islet β cell secretion deficiency and( or) the decreased insulin sensitivity of target tissue are the important pathophysiological mechanisms of diabetes. So,detection and assessment of isletβcell function in the early stages,could be of great significance for disease severity evaluation,early intervention and prognosis of the disease. At present,the main methods of the testing and assessment ofβcell function includeβcell function evaluating indexes,pulsatile insulin secretion,insulin secretion by glucose or non-glucose secretagogues and func-tion testing by other secretions of isletβcells. Among of them,βcell functional assessment methods by detecting C-peptide( especially aspects such as 90 minutes of C-peptide testing in mixed-meal tolerance test,urinary C-pep-tide creatinine ratio) have experienced some progress in recent years.
