Acute kidney injury in newborns and chronic kidney disease
10.3760/cma.j.issn.1673-4408.2015.04.012
- VernacularTitle:新生儿急性肾损伤与慢性肾脏病
- Author:
Jianlu XIE
;
Shaoji LIU
- Publication Type:Journal Article
- Keywords:
Neonate;
Premature;
Acute kidney injury;
Chronic kidney disease
- From:
International Journal of Pediatrics
2015;(4):405-408
- CountryChina
- Language:Chinese
-
Abstract:
Once umbilical cord ligation,neonatal kidney will be responsible for maintaining the whole-body homeostasis and the excretory requirements of the newborn. Meanwhile,there is a significant physiologic changes that occurs during the transition from intrauterine to extrauterine life. Neonatal renal reserve is less than adults,for the structure and function of the kidney still undergo a maturation process. Under the normal condi-tion,the adaptive changes of the renal function,with neonatal growth and development,can keep a delicate bal-ance of the internal environment. If they are exposed to a variety of external stressors,their immature kidney is especially vulnerable,which will not only cause fluid,electrolyte and acid-base imbalances and the adverse prog-nosis,but effect kidney structure and function further mature and increase the long-term risk of chronic kidney disease as well.
