Clinical significance of adenosine deaminase in tuberculosis pleuritis in children
10.3760/cma.j.issn.1673-4408.2015.04.023
- VernacularTitle:腺苷脱氨酶在儿童结核性胸膜炎的诊断意义
- Author:
Wei WANG
;
Xiaoxia PENG
;
Hongyan CUI
;
Hui LIU
;
Haiming YANG
;
Shunying ZHAO
- Publication Type:Journal Article
- Keywords:
Adenosine deaminase;
Pleural effusion;
Children;
Diagnosis;
Tuberculosis pleuritis
- From:
International Journal of Pediatrics
2015;(4):447-449
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of adenosine deaminase ( ADA) in pleural ef-fusion for diagnosis of tuberculosis pleuritis in children. Methods The level of ADA in pleural effusion was ret-rospectively analyzed in 28 cases with purulent pleuritis,thirty-four cases with mycoplasma pneumoniae pleuri-tis,forty-five cases with tuberculosis pleuritis from July 2011 to January 2014 in Beijing Children′s Hospital Af-filiated to Capital Medical University. Results The level of ADA in three groups was expressed by median (range interquartile). ADA in the purulent pleuritis group [126. 35 (76. 80,178. 13)U/L]was higher than the group of mycoplasma pneumoniae pleuritis [ 55. 55 ( 42. 80, 79. 03 ) U/L ] and tuberculosis pleuritis [ 26. 50 (22. 05,50. 95)U/L]. The difference was statistically significant (P< 0. 01). The cut-off value of pleural effu-sion ADA for diagnosis of tuberculosis pleuritis is not available by application of ROC curve. Conclusion Higher ADA value is not only the characteristic of tuberculosis pleuritis,but also purulent pleuritis and mycoplas-ma pneumoniae pleuritis. ADA has no clinical value in diagnosis of tuberculosis pleuritis in children.
