Therapeutic effect of combined therapy of esmolol hydrochloride and amlodipine on patients with hy-pertension complicated aortic dissection
10.3969/j.issn.1008-0074.2015.03.21
- VernacularTitle:盐酸艾司洛尔并氨氯地平治疗高血压并主动脉夹层的疗效
- Author:
Yingwen CHEN
;
Yanxian WU
;
Caihua LI
;
You YANG
;
Yuying CHEN
;
Yiwen ZHANG
;
Demou LUO
- Publication Type:Journal Article
- Keywords:
Hypertension;
Aortic diseases;
Amlodipine;
Esmolol
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(3):300-303
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore therapeutic effect of esmolol hydrochloride combined amlodipine on patients with hyper-tension complicated aortic dissection (AD) and its influence on patient's blood pressure (BP) and heart rate (HR) .Meth-ods:A total of 110 patients with hypertension complicated AD were randomly and equally divided into amlodipine group and combined treatment group (received amlodipine and esmolol) .Results:Compared with before treatment , after treat-ment 0. 5 ,1. 5 and 7h ,there were significant reductions in systolic blood pressure (SBP) and diastolic blood pressure (DBP) in both groups ,P<0.01 ,on 7h after treatment ,SBP level of combined treatment group significantly reduced than that of amlodipine group [(101.5 ± 7.8) mmHg vs .(123.4 ± 10.2) mmHg ,P<0.01];on 0.5 ,1.5 and 7h after treatment ,HR and rate pressure product (RPP) of combined treatment group significantly reduced than those of amlodipine group , P<0. 01 all. Compared with amlodipine group after treatment , there were significant rise in standard-reaching rates of BP (56.36% vs .87.27% ) ,HR (38.18% vs .92.73% ) and BP+HR (25.45% vs .81.82% ) in combined treatment group , P<0.01 all. Conclusion:Esmolol combined amlodipine can control blood pressure and heart rate rapidly ,safely and effec-tively in patients with hypertension complicated aortic dissection .
