Advances in inflammasome and inflammasome-related diseases
10.3969/j.issn.1000-484X.2015.06.001
- VernacularTitle:炎症小体及其相关疾病的研究进展
- Author:
Yan WANG
;
Bing SUN
- Publication Type:Journal Article
- Keywords:
Inflammasome;
Inflammatory diseases;
Regulation mechanism
- From:
Chinese Journal of Immunology
2015;(6):721-727
- CountryChina
- Language:Chinese
-
Abstract:
Inflammasomes are multi-protein complexes that trigger the activation of caspase-1 and the maturation of interleukin-1β ( IL-1β) , which are critical for inflammation and control of pathogen infection. Inflammasomes are involved in and regulate diversified diseases due to its capability to sense multiple danger signals. In this review, we present the activation and regulation mechanisms for different inflammasomes and discuss how genetic mutations in inflammasome-related genes or abnormal activity of in-flammasomes lead to diseases. Insights into the role of inflammasome in various human diseases will provide sound theoretical basis and effective treatment strategy for these disease.
