Relationship of clinical outcomes and expression of microRNA-199 a/b-3 p in HCC
10.3969/j.issn.1000-484X.2015.06.019
- VernacularTitle:microRNA-199 a/b-3 p表达与肝细胞癌临床预后的相关性
- Author:
Lei LIU
;
Shouqing LI
;
Xuguang MI
;
Yanqiu FANG
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
microRNA-199a/b-3p;
Cum survival
- From:
Chinese Journal of Immunology
2015;(6):806-808
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of microRNA-199a/b-3p (miR-199a/b-3p) in hepatocellular carcinoma ( HCC) tissues,and to explore the relationship with clinical outcomes. Methods: Real time quantitative PCR technique was used to measure the expression of miRNA-199a/b-3p in HCC tissues. The correlation between miR-199a/b-3p expression and the clinic pathological features of patients were analyzed. Results: Comparing with adjacent control, miRNA-199a/b-3p presented lower expressions in HCC tissues (P<0. 05);lower miR-199a/b-3p was found correlated with metastasis and poor survival. Conclusion:MiR-199a/b-3p take a crucial role in HCC metastasis and recurrence.
