Influence of hemoperfusion on microinflammatory state and atherosclerosis in uremic patients

VernacularTitle:血液灌流对尿毒症患者微炎症状态和动脉粥样硬化的影响
Author: Bo YUAN ; Jianjun YANG ; Mei TIAN ; Yunmei LI ; Zeying LIU ; Min SHEN ; Yangjie HE
Publication Type:Journal Article
Keywords: uremia; hemoperfusion; microinflammatory state; coronary artery disease
From: Chongqing Medicine 2015;(14):1900-1901
CountryChina
Language:Chinese
Abstract: Objective To observe the influence of hemoperfusion(HP) on microinflammatory state and atherosclerosis in uremic patients .Methods Thirty‐six patients with uremia were randomly assigned into 2 groups ,18 cases in eath group .The hemo‐dialysis(HD) group took hemodialysis for 3 times per week ,4 h per time;the HP+ HD group took once HP per week on the basis of HD .The levels of C‐reactive protein(CRP) ,total cholesterol(TC) ,triglyceride(TG) ,urea nitrogen(BUN) and serum creatinine (Cr) were measured before therapy and in six months after therapy .The atherosclerotic plaque size was detected by ultrasound with fine resolution .Results The levels of CRP ,TG and TC after treatment in the HP+ HD group were significantly decreased com‐pared with those before treatment and the HD group (P<0 .05) .The number of therosclerotic plaques in the HP+ HD group had no increase .BUN and Cr had no statistical differences between the two groups(P>0 .05) .Conclusion HP can alleviate the inflam‐matory reaction and decrease the atherosclerosis occurrence .