Research on expression of TNF-α in intrahepatic cholestasis of pregnancy

VernacularTitle:TNF-α在妊娠期肝内胆汁淤积症中表达的研究
Author: Ying HUANG
Publication Type:Journal Article
Keywords: cholestasis; intrahepatic; tumor necrosis factor-α; pregnancy; glycocholic acid; total bile acid
From: Chongqing Medicine 2015;(14):1913-1915
CountryChina
Language:Chinese
Abstract: Objective To investigate the influence of total bile acid (TBA) ,cholyglycine(CG) ,biochemical parameters of liv‐er ,tumor necrosis factor‐α(TNF‐α) in the patients of intrahepatic cholestasis of pregnancy (ICP) on parturients and perinatal new‐borns .Methods The clinical data in 164 cases of ICP in our hospital from January 2012 to December 2013 were retrospectively ana‐lyzed .TBA ,CG and TNF‐αwere detected by the radioimmunoassay and TBIL ,DBIL ,ALT and AST were analyzed by the biochemi‐cal analyzer .Results TBA ,CG ,TBIL ,DBIL and ALT in the patients with ICP were increased than those in normal pregnant women ,i .e .the liver function was damaged ,serum TNF‐αexpression was increased ,the above indexes in the patients with severe ICP were increased compared with the mild ICP patients ,postpartum hemorrhage volume was increased and the Apgar scores were decreased (P<0 .05) .Conclusion ICP is high risk pregnancy .TNF‐α,CG and TBA reflect the severity degree of ICP .