Therapeutic effect of atorvastatin therapy of different doses on acute coronary syndrome
10.3969/j.issn.1008-0074.2015.03.28
- VernacularTitle:不同剂量阿托伐他汀治疗急性冠脉综合征的疗效
- Author:
Zhengyuan YUAN
;
Zijie XIAO
- Publication Type:Journal Article
- Keywords:
Acute coronary syndrome;
Adiponectin;
Atorvastatin
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(3):322-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the optimal dose of atrovastatin treating acute coronary syndrome (ACS) .Methods:A total of 86 ACS patients were randomly and equally divided into atorvastatin large dose group (40 mg/d) and rou-tine dose group (20 mg/d ) . Blood lipid levels , blood lipid standard-reaching rate , serum levels of adiponectin (APN) and high sensitive C reactive protein (hsCRP) were compared between two groups before and after treat-ment .All patients were followed up for six months after discharge ,and incidence rates of cardiovascular events and adverse reactions were compared between two groups .Results:Compared with routine dose group ,the levels of TC and LDL-C significantly reduced on 3 months after treatment ,in large dose group (P<0.01 ,<0.05 respectively);the standard-reaching rates of TC and LDL-C [TC:(23.3% vs .44.2% ) ,LDL-C:(37.2% vs .60.5% ) ,P<0.05 all];level of APN [ (8.47 ± 1.73) mg/L vs .(12.96 ± 2.15) mg/L] significantly rose ,level of CRP [ (6.23 ± 1.26) mg/L vs .(4.07 ± 1.54) mg/L] significantly reduced ,P<0.01all;incidence rate of adverse cardiovascular e-vents (23.3% vs .7.0% , P= 0.035) significantly reduced ,but there was no significant difference in incidence rate of adverse reactions between two groups ,P=0.213.Conclusion:Atorvastatin therapy can effectively reduce in-cidence rate of cardiovascular events in ACS patients ,and the dose 40mg/d is optimal dose .
