Preliminary Study on the Biological Basis of TCM Syndromes Based on Literature Mining

VernacularTitle:基于文献挖掘的中医证候生物学基础初步研究
Author: Jingwei LIU ; Xing ZHAI ; Xuanchao FENG ; Kuo GAO ; Huihui ZHAO ; Kun CHEN ; Jia LIU ; Jianxin CHEN
Publication Type:Journal Article
Keywords: TCM syndromes; qi deficiency syndrome; literature mining; biological basis; NEI
From: Chinese Journal of Information on Traditional Chinese Medicine 2015;(7):43-46
CountryChina
Language:Chinese
Abstract: Objective To explore the biological basis of TCM syndromes from a biomolecules network perspective with qi deficiency syndrome as the breakthrough point. Methods A data dictionary of neuro-endocrine-immune (NEI) related genes and qi deficiency syndrome characterization terminology thesaurus were established. Literature about qi deficiency syndrome characterization was retrieved by using Genclip, to excavate the characteristic NEI gene, thereby to explore different bioactive substances of syndromes. Results The analysis of the genetic data, showed qi deficiency related cluster with the relevance of endocrine, signal transduction, hematopoietic cell and immune deficiencies etc. It is confirmed that the intrinsic biological features of TCM syndrome can effectively identify in the NEI level. Conclusion Literature mining method as a new way to discover syndromes biological indicators has certain feasibility, and it is recommended to be further expanded into other studies on syndromes to validate the universality and reliability of this method.