Effects of Amygdalin on TNF-α and sICAM-1 of Rats with Type II Collagen-induced Arthritis

VernacularTitle:苦杏仁苷对Ⅱ型胶原诱导性关节炎大鼠肿瘤坏死因子-α和细胞间黏附分子-1的影响
Author: Demei LUO ; Zhigui SHAN ; Jinlian GE ; Qing LIU ; Li LUO
Publication Type:Journal Article
Keywords: amygdalin; type II collagen-induced arthritis; TNF-α; sICAM-1; rats
From: Chinese Journal of Information on Traditional Chinese Medicine 2015;(7):75-77
CountryChina
Language:Chinese
Abstract: Objective To discuss effects of anti-inflammatory mechanism of amygdalin on rats with type II collagen-induced arthritis (CIA). Methods Wistar rats were randomized into normal group, model group, amygdalin group, and tripterygium group. Type II CIA rat models were established. From the 15th day after the modeling establishment, each administration group was given corresponding dose of medicine for continuous 28 days. Levels of TNF-αand sICAM-1 were detected by ELISA in serum of rats, and expression of TNF-α was detected by immuno-histochemical method. Results TNF-α positive expression in amygdalin group and tripterygium group was similar and significantly reduced compared with model group. Levels TNF-α and sICAM-1 in amygdalin group and tripterygium group significantly decreased compared with those in model group (P<0.05), without significant difference compared with normal group (P>0.05). Conclusion Amygdalin can inhibit the expression of TNF-α and levels of TNF-α and sICAM-1, in order to treat rheumatoid arthritis.