New understanding of complement in childhood immune and/or inflammatory renal diseases
10.3969/j.issn.1000-3606.2015.06.002
- VernacularTitle:补体在儿童免疫和/或炎症性肾脏疾病中的新认识
- Author:
Huijie XIAO
;
Ke XU
;
Jie DING
- Publication Type:Journal Article
- Keywords:
complement;
gene;
renal disease;
child
- From:
Journal of Clinical Pediatrics
2015;(6):504-510
- CountryChina
- Language:Chinese
-
Abstract:
The complement system, the chief component of innate immunity, is not only required for host defense against pathogens and homeostasis, but also related to the pathogenesis and development of various kidney diseases. Recent study has shown that tissue-derived complement and immune cell-derived complement can each mediate local inlfammation. The comple-ment system acts as a bridge between innate and adaptive immunity. Furthermore it’s also a functional bridge between pathogenic humoral and cellular immune responses in an array of kidney diseases. Increasing evidence links inappropriate complement acti-vation and deifciencies of complement proteins to the pathogenesis of kidney autoimmune disease, ischemia-reperfusion injury, transplant rejection and complications in hemodialysis. The development of pharmacologic agents that target complement in pa-tients with this assortment of immune and/or inlfammatory kidney diseases has the potential to abrogate disease progression and improve patient health.
