Analysis of clinical pathology of the IgA nephropathy and purpura nephritis in children from the perspective of IgA vasculitis
10.3969/j.issn.1000-3606.2015.06.003
- VernacularTitle:从IgA血管炎角度分析儿童IgA肾病和紫癜性肾炎的临床病理
- Author:
Cuirong DUAN
;
Huijie XIAO
;
Xuhui ZHONG
;
Fang WANG
;
Na GUAN
;
Xiaoyu LIU
;
Jie DING
- Publication Type:Journal Article
- Keywords:
IgA vasculitis;
IgA nephropathy;
Henoch-Sch?nlein purpura;
Henoch-Sch?nlein purpura nephritis;
child
- From:
Journal of Clinical Pediatrics
2015;(6):511-514
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To analysis clinical pathology of organ speciifc IgA vasculitis (IgA nephropathy) and systemic IgA vasculitis (allergic purpura) of purpura nephritis in children. Methods Clinical and pathological data of hospitalized pediatric patients of IgA nephropathy and purpura nephritis were retrospectively analyzed from June 1993 to November 2014. Results There were 405 patients of IgA nephropathy (256 males and 149 females). The ratio of male to female was 1.7:1. The average age was 10.2±2.8 years. The nephrotic syndrome (31.6%) was the most common clinical type, followed by hematuria and proteinuria (27.9%). There were 548 patients of purpura nephritis, 329 males and 219 females. The ratio of male to female was 1.5:1. The average age was 10.2±3.1 years. The hematuria and proteinuria (61.6%) was the most common clinical type, followed by nephrotic syndrome (21.4%). None of the IgA nephropathy progressed to systemic vasculitis (allergic purpura). Conclusions The causes, onset ages and clinical manifestations of IgA nephropathy and allergic purpura may be consistent or overlap, but none of IgA nephropathy (organ speciifcity IgA vasculitis) progressed to allergic purpura (systemic IgA vasculi-tis). IgA nephropathy might have more renal immune disorder mechanisms involved in its pathogenesis.
