Steroid-resistant nephrotic syndrome accompanied with irreversible leukoencephalopathy：one case report
10.3969/j.issn.1000-3606.2015.06.007
- VernacularTitle:激素耐药型肾病综合征伴不可逆性脑白质病变1例报告
- Author:
Jianjun WANG
;
Chun WU
;
Zengrong LIU
;
Si WANG
;
Jie YANG
;
Xiaojiang LU
;
Li QIN
- Publication Type:Journal Article
- Keywords:
steroid-resistant nephrotic syndrome;
irreversible leukoencephalopathy;
child
- From:
Journal of Clinical Pediatrics
2015;(6):528-530
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To analyze the diagnosis and management of steroid-resistant nephrotic syndrome (SRNS) accompanied with irreversible leukoencephalopathy in children. Methods The clinical, laboratory and imaging data were retrospectively analyzed in a SRNS child accompanied with irreversible leukoencephalopathy. A literature review was performed. Results After clinical diagnosis of SRNS, glucocorticoid, immunosuppressant, and hemodialysis were administrated for 10 months. During the course of treatment, the seizures, visual problems, and hypertension were repeatedly occured. The cranial MRI showed bilateral occipital parietal lobe hyperintensity and right frontotemporal lobe hyperintensity on T2-weighted imaging and bilateral occipital parietal lobe hypointensity on T2-Flair imaging, which indicated that encephalomalacia was accompanied with gliosis. Conclusions A variety of reasons may induce leukoencephalopathy in children. The accompanied irreversible leu-koencephalopathy should be strongly considered in management of SRNS.
