Effects of Modified Jianpi Yishen Decoction on Urinary Osteopontin of Calcium Oxalate Nephrolithiasis Patients After Operation
10.3969/j.issn.1005-5304.2015.07.011
- VernacularTitle:加味健脾益肾方对草酸钙肾结石患者术后尿骨桥蛋白的影响
- Author:
Yan WANG
;
Feng LIN
;
Xueyun WENG
;
Xumin XU
;
Shaolong YU
;
Zhifeng CHEN
;
Zhipeng WEN
- Publication Type:Journal Article
- Keywords:
modified Jianpi Yishen Decoction;
kidney stone;
calcium oxalate;
PCNL;
URL;
urinary osteopontin
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(7):36-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of modified Jianpi Yishen Decoction on urinary osteopontin (OPN) in calcium oxalate nephrolithiasis patients after percutaneous nephrolithotomy (PCNL) or ureteroscope lithotomy (URL);To clarify the mechanism of modified Jianpi Yishen Decoction on the prevention of calcium oxalate kidney stones. Methods Totally 116 calcium oxalate nephrolithiasis patients were randomly divided into trial group (62 cases) and control group (54 cases). The trial group took modified Jianpi Yishen Decoction every other day, while the control group took potassium sodium hydrogen citrate granules three times a day. The concentrations of OPN, urinary calcium and urinary oxalic acid of the patients in the two groups were observed before treatment and 2 weeks and 4 weeks of treatment. Results The concentration of urinary OPN of 2 weeks and 4 weeks of the treatment in the trial group was significantly increased compared with before treatment (P<0.05), and the difference was statistically significant compared with the control group (P<0.05). The concentration of urinary OPN in the control group had no significant change after treatment (P>0.05). The differences in the concentrations of urinary calcium and urinary oxalic acid of the two groups between before and after treatment were not significant (P>0.05). Conclusion Modified Jianpi Yishen Decoction can effectively restrain the formation of the calcium oxalate stones by increasing the level of urinary OPN, which demonstrates effective prevention in the calcium oxalate nephrolithiasis patients after PCNL or URL.
