Risk and protective factors of periventricular-intraventricular hemorrhage in preterm infants
10.3969/j.issn.1000-3606.2015.06.012
- VernacularTitle:早产儿脑室周围-脑室内出血的高危因素和保护因素
- Author:
Yinquan XU
;
Ya DONG
;
Zhenlang LIN
- Publication Type:Journal Article
- Keywords:
periventricular-intraventricular hemorrhage;
risk factors;
protective factor;
preterm
- From:
Journal of Clinical Pediatrics
2015;(6):548-552
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify risk and protective factors of the periventricular-intraventricular hemorrhage (PV-IVH) in preterm infants. Methods By 1:1 case-control study, prenatal and perinatal data were collected and analyzed between preterm infants with PV-IVH and control group from January 2012 to October 2014. The risk and protective factors for the PV-IVH were identiifed by univariate analysis and multivariate conditional logistic regression analysis. Results There were one hundred and thirty-two preterm infants diagnosed of PV-IVH, in which, among whom 6 preterm infants could not be matched to the control infants in the protocol. Finally, 126 pairs of infants were enrolled in the study. There were no differences between two groups in gestational age and birth weight (all P>0.05). Multivariate conditional logistic regression analysis found that BE<-5 mmol/L in the initial blood gas analysis after birth (OR=1.986, 95.0%CI:1.039-3.796), mechanical ventilation (OR=2.913, 95%CI:1.390-6.101), weight gain≤10 g/d in the second week (OR=2.303, 95%CI:1.164-4.558) were risk factors, while number of previous pregnancies≥1 times (OR=0.426, 95%CI:0.229-0.792) was a protective factor for PV-IVH. Conclusions The risk factors of PV-IVH in preterm infants include the lower BE value in the initial blood gas analysis, required mechanical ventilation, and less weight gain in the second week.
